– Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis (Environmental Health Perspectives):
Background: Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children’s neurodevelopment.
Objective: We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.
Methods: We searched the MEDLINE, EMBASE, Water Resources Abstracts, and TOXNET databases through 2011 for eligible studies. We also searched the China National Knowledge Infrastructure (CNKI) database, as many studies on fluoride neurotoxicity have been published in Chinese journals only. In total, we identified 27 eligible epidemiological studies with high and reference exposures, endpoints of IQ scores or related cognitive function measures with means and variances for the two exposure groups. We estimated the standardized mean difference (SMD) between exposed and reference groups across all studies using random effects models. We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking water fluoride as the only exposure. Cochran test for heterogeneity between studies, Begg’s funnel plot and Egger test to assess publication bias were performed. Meta-regressions to explore sources of variation in mean differences among the studies were conducted.
Results: The standardized weighted mean difference in IQ score between exposed and reference populations was -0.45 (95% CI -0.56 to -0.35) using a random-effects model. Thus, children in high fluoride areas had significantly lower IQ scores than those who lived in low fluoride areas. Subgroup and sensitivity analyses also indicated inverse associations, although the substantial heterogeneity did not appear to decrease.
Conclusions: The results support the possibility of an adverse effect of high fluoride exposure on children’s neurodevelopment. Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.
Citation: Choi AL, Sun G, Zhang Y, Grandjean P 2012. Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp.1104912
Received: 30 December 2011; Accepted: 20 July 2012; Online: 20 July 2012
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Fluoride is THE main ingredient in rat poison.
Fluoride is THE main ingredient in Sarin nerve gas.
Fluoride is THE main ingredient in Prozac.
Fluoride destroys the brain (accumulates in the pineal gland and causes it to calcificate), the bones, the organs, rips the DNA apart and causes cancer.
Hitler and Stalin used it in concentration camps and gulags as mass control instrument to make the prisoners docile and infertile.
More on fluoride (and lithium):
– 32nd Largest US city Ends Water Fluoridation
– Former Governor Jesse Ventura: It Was The Nazis That First Put Fluoride Into Water! Fluoride Is the MAIN INGREDIENT In Prozac! (Video)
– New Hampshire Passes Fluoride Warning Bill: Water Fluoridation Persists Despite Being Unhealthy for Infants
– Interview With Neurosurgeon Dr. Russell Blaylock On MSG And Brain-Damaging Excitotoxins (Video)
– The Great Culling – A Hard-Hitting Film About Water, Fluoride, Food, Vaccines And More
– The Bizarre History Of Fluoride (Documentary)
– Mobile Fluoride Vans To Target Communities That Voted To Remove Chemical From Public Water Supply
– The Beautiful Truth (Video – Full Documentary – The Many Reasons For Chronic Diseases And The Cure)
– Ireland: Psychiatrist Dr. Moosajee Bhamjee Calls For Lithium To Be Added To Water
– 11 Shocking Things You Now Realize To Be True (But You Never Would Have Believed Just Three Years Ago)
– Former FBI Chief Ted Gunderson: Chemtrail ‘Death Dumps’ Must Be Stopped! – ‘This Is Genocide … This Is Murder By The United Nations!’
– ALERT: Stunning Undercover Video Footage Of Toxic Fluoride Chemicals Being Pumped In Austin, Texas Water Supply
– New Study: Fluoride Can Damage the Brain – Avoid Use in Children
– And Now: Lithium – The Next Fluoride – To Be Added To Your Drinking Water For Mental Health (Mind-Control)
– Ministers Unveil Plans To Fluoridate All Drinking Water In England And Wales
– The Fluoride Deception (Mini Documentary): Industrial Highly Toxic Waste Chemicals Passed Off As Medicine
– EXPOSED Drinking Water Contains Chinese Industrial Fluoride Which Has Additional UNKNOWN Substance In It
– Food: The Ultimate Secret Exposed
– CDC Reduces Fluoride Poisoning of America’s Water Supply, Admits That 2 in 5 Children Show Signs of Fluoride Poisoning
– Study: Fluoride in Water Linked to Lower IQ in Children
– Jesse Ventura Conspiracy Theory: Worldwide Water Conspiracy
– Fluoride: A Chronological History (Must-read!)
– Scientific Facts on the Biological Effects of Fluoride
– The Drugging Of America with Fluoride
– Fluoride & The Manhattan Project (Declassified Government Documents)
– Fluoride: A Toxic Poison That Accumulates In The Pineal Gland
– Fluoridation: A Horror Story
– Fluoride: The Phosphate Connection
– Fluoride Poisoning Affects Millions in China’s Guizhou Province
– The Age of Treason: 1958 Book Exposes Current Chemical Attack on Humanity
– Guess where your fluoride contaminated with heavy metals comes from? China!
– India: Fluoride Poisons Children in Jharkhand, Causes Acute Dental and Skeletal Disorders
– Chinese Fluoride In Mass. Water Raises Concern
– Govt. Report Says Fluoride Added to Water Supply May Harm Population
– California Begins Poisoning Millions with Toxic Synthetic Fluoride Chemicals
– Health Professionals Call for End to Water Fluoridation:
Over 1,600 Professionals Call for an End to Fluoridation of Drinking Water
– Professional Perspectives: Fluoride in Tap Water
– Fluoride, Aspartame and Agenda 21