Apoptosis

Dichloroacetate (DCA) Causes Cancer Cells to Self-Destruct – Study: Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo

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– Dichloroacetate (DCA): This New Drug Appears to Cause Cancer Cells to Self-Destruct:

By Dr. Mercola

According to the American Cancer Society, the odds you’ll develop cancer in your lifetime are one in two, if you’re a man, and one in three, if you’re a woman.1 But an experimental cancer drug shown to shrink tumors by correcting metabolic oddities in cancer cells shows promise in the fight against this deadly disease. The synthetic drug DCA (dichloroacetate) DOES indeed kill cancer cells, both in the lab and in human beings. However, whether it can reverse tumor growth without harming you in other ways remains to be seen.

Read moreDichloroacetate (DCA) Causes Cancer Cells to Self-Destruct – Study: Dichloroacetate is an effective treatment for sarcoma models in vitro and in vivo

Bitter melon can stop cancer cells from growing and spreading and is also effective against type-2 diabetes

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– Bitter melon can stop cancer cells from growing and spreading:

A popular Asian fruit that looks kind of like a cucumber with warts, bitter melon has a long history of use in traditional cooking, holding a prominent place in both Indian and Chinese cuisine. But recent research out of St. Louis University (SLU) shows that bitter melon serves as a whole lot more than just a tasty gourd, showing viability in the prevention and treatment of cancer.

With the help of a $40,000 grant from the Lottie Caroline Hardy Charitable Trust, researchers from SLU are expanding their investigation into the anti-cancer effects of bitter melon, which has already shown that the fruit can prevent the growth and spread of breast cancer cells. This time around, Dr. Ratna Ray, Ph.D., a longtime advocate of bitter melon for medicinal use, is looking into how the fruit can help prevent prostate and other forms of cancer.

Read moreBitter melon can stop cancer cells from growing and spreading and is also effective against type-2 diabetes

Virginia man tasered 20 times in 30 minutes dies in police custody

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– Virginia man tasered 20 times in 30 minutes dies in police custody:

Linwood Lambert was tasered outside a hospital, arrived unconscious at police station and was pronounced dead by the time he was taken back to hospital.

Video has emerged showing three police officers tasing a man 20 times in 30 minutes while handcuffed.

The incident took place in May 2013 in South Boston, a small town in southern Virginia; and it is receiving renewed attention after a MSNBC report on Wednesday.

Read moreVirginia man tasered 20 times in 30 minutes dies in police custody

How Turmeric Reduces Oxidative Stress and Supports Your Brain and Heart

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– How Turmeric Reduces Oxidative Stress and Supports Your Brain and Heart (Waking Times, June 13, 2013):

Curcumin has increasingly come under the scientific spotlight in recent years, with studies investigating its potential health benefits. It has even been found to outperform pharmaceuticals in preventing disease. Curcumin is a compound found in the spice turmeric which gives it a natural pigment. It has been linked to a range of health benefits, including potential protection against prostate cancer, Alzheimer’s, protection against heart failure, diabetes, and arthritis. Two studies add to that mix with benefits for arterial aging and cognition.

The first of the news studies, published in Experimental Gerontology and performed by scientists from the University of Colorado, found that curcumin was associated with improved vascular health in aging lab mice.

Curcumin is a diferuloylmethane derived from turmeric (popularly called “curry powder”) that has been shown to interfere with multiple cell signaling pathways, including cell cycle, proliferation, survival, invasion, metastasis and inflammation.

Adding curcumin to human cells with the blood cancer multiple myeloma, Dr. Bharat B. Aggarwal of the University of Texas MD Anderson Cancer Center in Houston and his colleagues found, stopped the cells from replicating. And the cells that were left died.

Read moreHow Turmeric Reduces Oxidative Stress and Supports Your Brain and Heart

Study: Grape Seed Extract Kills Head And Neck Cancer Cells, Leaves Healthy Cells Unharmed

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Flashback:

– Study: Grape Seed Extract Kills 76% Of Leukemia Cancer Cells In 24 Hours:

A new study conducted at the University of Kentucky in the United States, and published in the journal Clinical Cancer Research, found that leukemia cancer cells exposed to grapeseed extract (GSE) were rapidly killed through a process of cell suicide known as “apoptosis.”

In these laboratory studies, an astonishing 76% of leukemia cells committed suicide within 24 hours thanks to the ability of GSE to activate a protein called JNK, which regulates apoptosis.

In short, this works for all cancers, BUT it cannot be patented (like all the other inexpensive natural cancer cures), which is why the chemotherapy, radiation and surgery concentration camps still exist.

Follow the money!

– Grape seed extract kills head and neck cancer cells, leaves healthy cells unharmed (Medical Xpress, Jan. 27, 2012):

A study published this week in the journal Carcinogenesis shows that in both cell lines and mouse models, grape seed extract (GSE) kills head and neck squamous cell carcinoma cells, while leaving healthy cells unharmed.

“It’s a rather dramatic effect,” says Rajesh Agarwal, PhD, investigator at the University of Colorado Cancer Center and professor at the Skaggs School of Pharmaceutical Sciences.

It depends in large part, says Agarwal, on a healthy cell’s ability to wait out damage.

“Cancer cells are fast-growing cells,” Agarwal says. “Not only that, but they are necessarily fast growing. When conditions exist in which they can’t grow, they die.”

Grape seed extract creates these conditions that are unfavorable to growth. Specifically, the paper shows that grape seed extract both damages cancer cells’ DNA (via increased reactive oxygen species) and stops the pathways that allow repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51 and DNA repair foci).

“Yet we saw absolutely no toxicity to the mice, themselves,” Agarwal says.

Read moreStudy: Grape Seed Extract Kills Head And Neck Cancer Cells, Leaves Healthy Cells Unharmed

Government Study: THC From Cannabis Kills Cancer Cells

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– Government Study Proves THC from Cannabis Destroys Cancer Cells (Big Health Report, August 30, 2011):

Medicinal marijuana oil made from cannabis buds, when ingested thrice daily, for two months, will destroy leukemia and cancer cells.  Here is just one study which shows the results:
http://www.ncbi.nlm.nih.gov/pubmed/16908594:

Abstract

Plant-derived cannabinoids, including Delta9-tetrahydrocannabinol (THC), induce apoptosis in leukemic cells, although the precise mechanism remains unclear. In the current study, we investigated the effect of THC on the upstream and downstream events that modulate the extracellular signal-regulated kinase (ERK) module of mitogen-activated protein kinase pathways primarily in human Jurkat leukemia T cells. The data showed that THC down-regulated Raf-1/mitogen-activated protein kinase/ERK kinase (MEK)/ERK/RSK pathway leading to translocation of Bad to mitochondria. THC also decreased the phosphorylation of Akt. However, no significant association of Bad translocation with phosphatidylinositol 3-kinase/Akt and protein kinase A signaling pathways was noted when treated cells were examined in relation to phosphorylation status of Bad by Western blot and localization of Bad to mitochondria by confocal analysis. Furthermore, THC treatment decreased the Bad phosphorylation at Ser(112) but failed to alter the level of phospho-Bad on site Ser(136) that has been reported to be associated with phosphatidylinositol 3-kinase/Akt signal pathway. Jurkat cells expressing a constitutively active MEK construct were found to be resistant to THC-mediated apoptosis and failed to exhibit decreased phospho-Bad on Ser(112) as well as Bad translocation to mitochondria. Finally, use of Bad small interfering RNA reduced the expression of Bad in Jurkat cells leading to increased resistance to THC-mediated apoptosis. Together, these data suggested that Raf-1/MEK/ERK/RSK-mediated Bad translocation played a critical role in THC-induced apoptosis in Jurkat cells.

The government study was done by Jia W, Hegde VL, Singh NP, Sisco D, Grant S, Nagarkatti M,Nagarkatti PS at the Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA.

To quote: ”Cannabinoids including THC, induce apoptosis in leukemic cells” PMID: 16908594

Marijuana Compound Kills Brain Tumors in Humans

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Study: Grape Seed Extract Kills 76% Of Leukemia Cancer Cells In 24 Hours

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– Grapeseed Extract Kills 76% Of Leukemia Cancer Cells In 24 Hours (Natural News, Jan. 06, 2009):

A new study conducted at the University of Kentucky in the United States, and published in the journal Clinical Cancer Research, found that leukemia cancer cells exposed to grapeseed extract (GSE) were rapidly killed through a process of cell suicide known as “apoptosis.”

In these laboratory studies, an astonishing 76% of leukemia cells committed suicide within 24 hours thanks to the ability of GSE to activate a protein called JNK, which regulates apoptosis.

Read moreStudy: Grape Seed Extract Kills 76% Of Leukemia Cancer Cells In 24 Hours