– Dr Young: Roundup Herbicide Is Endocrine Disruptor in Human Cells at Drinking Water Levels (GMO Evidence, March 20, 2015):
Roundup is an endocrine disruptor and is toxic to human cells in vitro (tested in culture dishes in the laboratory) at levels permitted in drinking water in Australia, a new study has found.
This is the first study to examine the effects of glyphosate and Roundup on progesterone production by human female cells in an in vitro system that models key aspects of reproduction in women.
Glyphosate alone was less toxic to human cells than glyphosate in a Roundup formulation; both glyphosate and Roundup caused cell death which resulted in decreased progesterone levels – a form of hormone/endocrine disruption. Endocrine disruption did not precede the toxicity to cells but occurred after it. The decreases in progesterone concentrations were caused by reduced numbers of viable cells.
A 24h exposure to a concentration of glyphosate (in Roundup) similar to that recommended as an acceptable level for Australian drinking water caused significant cytotoxicity in vitro, which supports a call for long-term in vivo (in live animals) studies to characterise the toxicity of Roundup.
The possibility that Roundup has endocrine disrupting activity independent of its ability to kill or disable cells needs further study.
Endocrine disruption and cytotoxicity of glyphosate and roundup in human JAr cells in vitro
Find the Full Study Here: http://www.gmoevidence.com/wp-content/uploads/2015/03/IPTG-1-104.pdf
Authors: Fiona Young, Dao Ho, Danielle Glynn and Vicki Edwards
The toxicity of the active molecule in herbicides has been used to determine safe concentrations, because other components are considered inert. Roundup, which contains the active molecule Glyphosate, was described as an endocrine disrupter because non-cytotoxic concentrations inhibited progesterone synthesis in vitro.
Human chorioplacental JAr cells synthesise progesterone, and increase synthesis when stimulated by chorionic gonadotrophin (hCG), or the transduction molecule cAMP. JAr cells were exposed to two Roundup formulations, and compared with the same concentrations of glyphosate ± cAMP, or ± hCG for 1, 4, 24, 48 or 72h. The surviving viable cells were quantified using an MTT assay, and progesterone was measured in an ELISA.
hCG and cAMP stimulated progesterone synthesis by cells in vitro as expected. In contrast to previous reports, JAr cell death preceded decreased progesterone synthesis, and steroidogenesis was unaffected by low, non-cytotoxic concentrations of Roundup or glyphosate. Roundup was more cytotoxic than glyphosate alone; the 24h EC50 was 16mM for glyphosate, but 0.008mM when glyphosate was in a 7.2g/L Roundup formulation. Significant cytotoxicity was caused by glyphosate in Roundup (p<0.01) after 24h, and cytotoxicity was observed in vitro after exposure toa range of concentrations comparable to the Australian Drinking Water Guidelines.
Endocrine disruption effects were secondary to cytotoxicity. Roundup was more cytotoxic than the same concentration of glyphosate alone, indicating that the other constituents of the herbicide are not inert. There is a compelling need to conduct in vivo studies to characterise the toxicity of glyphosate in a Roundup formulation, to facilitate re-evaluation of existing public health guidelines.
More important information on Glyphosate (Roundup):
– WHO: Roundup Weedkiller Containing Glyphosate Is ‘Probably Carcinogenic To Humans’
– Same delusional people who say vaccines are safe also insist GMOs, glyphosate, aspartame, mercury and radiation are safe, too
– Pennsylvania Researchers Discover Glyphosate Herbicide in Honey and Soy Sauce
– Roundup-Ready GM Crops Leave Monarch Butterflies Close To Extinction
– GMOs And Glyphosate Discovered in Kellogg’s Froot Loops
– Dr. Jayasumana: Glyphosate Leads to 5-Fold Increase in Deadly Kidney Disease Risk
– Top MIT Scientist: Roundup Causes Autism
– Dr. Edward Group: GMO, Endocrine Disruptors … They Want You Dead And Totally Neutralized (Video)
– Dr. Santadino: Glyphosate (Roundup Ready) Destroys Earthworm Eisenia fetida Populations
– Another Independent Study Confirms Monsanto’s RoundUp Chemicals Are Lethal, Even in Small Doses
– Food Safety Experts Slam USDA over 2,4-D GM Crops Approval
– Chinese and International Experts Slam GMOs and Glyphosate at Beijing Conference
– Dr. Kru?ger: Glyphosate Increases Birth Defects In Piglets
– New Séralini Study Shows Monsanto’s Roundup Damages Sperm
– Glyphosate Decreases Yield, Seedling Quality Of Roundup Ready Soybeans; Increases Rate Of Fungal Disease
– The Glyphosate Toxicity Studies You’re Not Allowed to See
– Reactions To Republication Of Landmark Seralini GMO Study
– Republication Of The Séralini Study: Science Speaks For Itself
– Dr. Schinasi: Glyphosate Herbicides Linked to Non-Hodgkin’s Lymphoma
– Monsanto’s Darkest Secret: Roundup’s Effect On The Fetus
– 3 Studies Proving Highly Toxic Glyphosate Found In Urine, Blood, And Even Breast Milk
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– Brazil’s Federal Public Prosecutor Requests Total Ban Of Glyphosate Herbicides
– Dr Cattani: Roundup Causes Toxic Damage To Rat Brains
– Scientist Slams Biotech Industry Over Deadly Kidney Disease Epidemic
– Gov. Study: Roundup Weedkiller Found In 75% of Air And Rain Samples
– Monsanto’s Roundup Causes ‘Gluten Intolerance’
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– Study: Roundup And Glyphosate Toxicity Underestimated
– GMO And Monsanto Roundup: Glyphosate Weedkiller In Our Food and Water?
– Glyphosate In Monsanto’s Roundup Inhibits Natural Detoxification In Human Cells: Study
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– USDA Received Dire Pathogen Warning BEFORE Deregulating GM Alfalfa
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– GMO Technology, Glyphosate Toxicity Leaving Men Sterile
– Jeffrey Smith’s Full Presentation On Deadly GMO’s (Video)
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– Study: Roundup Herbicide 450-Fold Diluted Is Still Genotoxic
– Illinois Government Secretly Destroys Beekeeper’s Bees And 15 Years Of Research Proving Monsanto’s Roundup Kills Bees
– Farmers Sue Monsanto And US Tobacco Giants Knowingly Poisoned Argentinean Tobacco Farmers With Pesticides, Causing ‘Devastating Birth Defects’ In Their Children
– Monsanto Secretly Poisoning Population With Roundup – Scientist And Friends Attacked For Exposing Roundup Link To Birth Defects
– ROUNDUP: Birth Defects Caused By World’s Top-Selling Weedkiller, Scientists Say
– Roundup Birth Defects: Regulators Knew World’s Best-Selling Herbicide Causes Problems, New Report Finds
– Scientists Warn Of Dangerous New Pathogen From Roundup Ready Treated Monsanto GM Crops Causing Infertility And Spontaneous Abortions
– Roundup, GMOs linked to emergence of deadly new pathogen causing spontaneous abortions among animals
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– Study: Monsanto’s Roundup Kills Human Cells (Flashback)
– Scientist: Monsanto’s herbicide could cause brain, intestinal and heart defects in foetuses