Niacin: The Energizer Powering Your Cells And Fighting Cancer

Authored by Sina McCullough, Mercura Wang via The Epoch Times (emphasis ours),

Whether it is turning food into fuel, building cells, repairing DNA, detoxifying, recycling nutrients, or defending against oxidative stress, niacin provides the energy to keep it all running smoothly. Without it, your cells would be like a phone stuck with a 1 percent battery: desperately low on power and struggling to keep up!

But niacin does more than energize your body. It also plays a vital role in specific functions, like supporting skin health—a finding that dates back to the discovery of this remarkable vitamin.

In the 1910s, Dr. Joseph Goldberger, a U.S. Public Health Service medical officer, was investigating the mystery of pellagra. This debilitating disease was sweeping South Carolina and other parts of the world, leaving a trail of severe symptoms: rough, scaly skin, digestive issues, and mental disturbances, with a fatality rate of 40 percent. Tens of thousands were affected, and the cause was a mystery. Most thought it was an infectious disease.

Goldberger suspected pellagra wasn’t caused by a germ but by something missing from people’s diets. By restricting corn and adding foods like fresh milk, buttermilk, eggs, beans, and peas to the diets of pellagra patients, Goldberger showed the symptoms could be reversed. But what was the magic ingredient in these foods?

Years later, a biochemist identified niacin as the specific factor behind this dietary solution. It turns out that niacin was the key to preventing pellagra and restoring health.

Special Talents

Niacin has many talents and roles, but a few main ones are highlighted below.

1. Energizer

Niacin is the star player in your body’s grand energy production team. Fats, carbohydrates, and specific proteins are broken down into energy when you eat. Turning these foods into usable energy is where niacin truly shines. In the presence of oxygen, these nutrients travel through a series of pathways to transform the food you eat into energy, known as adenosine triphosphate (ATP), which powers nearly everything you do, from thinking to moving.

ATP is in constant demand but exists in only small, rapidly depleted amounts. To keep us alive, our cells must regenerate ATP continuously—and that’s where niacin steps in as a genuine “energizer.” Niacin, in the form of nicotinamide adenine dinucleotide (NAD), acts as the critical energy carrier in the pathways that convert nutrients into ATP, ensuring that despite our limited ATP stores, we always have a fresh supply ready to fuel every heartbeat, every breath, and every thought.

Without niacin, the body’s energy production would cease, making this nutrient essential for sustaining life itself.

2. Nerve Protector

Niacin has shown exciting potential in protecting the nervous system and combating neurological diseases. Pre-clinical trials suggest it could be beneficial for conditions like multiple sclerosis (MS), Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and glioblastoma.

Niacin helps repair the myelin that protects your nerves and reduces inflammation in the brain. A 2004 prospective study found an association between higher niacin intake and a lower risk of Alzheimer’s disease and cognitive decline. Niacin also speeds up the transformation of stem cells into nerve cells and helps those cells survive, even under oxidative stress.

3. Cancer Fighter

Niacin enhances DNA repair by maintaining cellular energy levels, preventing ATP depletion, and increasing excision repair, which is essential for reducing cancer risk. In clinical trials, niacin reduced the incidence of skin cancer. In patients with cancer, higher niacin intake increased the odds of survival. Niacin may also help prevent certain cancers, as niacin deficiency can impair DNA repair, thus leading to genomic instability and increased tumor development in rat models, including a higher risk of chemically induced leukemia.

Also, niacin has been shown to effectively reduce the incidence of premalignant actinic keratosis by 11 percent, squamous cell carcinoma by 30 percent, and basal cell carcinoma by 20 percent among cancer patients, compared to a placebo after a 12-month trial. Furthermore, if you have certain cancers, such as carcinoids, you may also need more niacin.

Other Talents

Niacin also helps in the production of reproductive and stress-related hormones, improves circulation, regulates the secretion of pro-inflammatory cytokines, and suppresses inflammation.

Fun Facts

• Niacin is not technically an essential vitamin because your liver and certain microbes in your intestine can make it from tryptophan, the amino acid famous for making you sleepy after Thanksgiving turkey.
• While some organizations discourage its use as a first-line therapy, the U.S. Food and Drug Administration (FDA) has approved niacin to treat high cholesterol and high triglycerides. Niacin was the first cholesterol-lowering drug before the discovery of statins.
• Unlike some of the other B vitamins, niacin is stable when exposed to heat and light. It survives most cooking methods, so the niacin in your food is unlikely to be destroyed during preparation.
• More than 400 enzymes depend on niacin, making it critical for proper body function.
• There’s growing interest in niacin’s role in the production of serotonin, a neurotransmitter that helps regulate mood, sleep, and appetite.

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